CX-7's rigid unibody uses the Mazda Advanced Impact energy Distribution and Absorption System to realize high levels of collision safety and helps to protect occupants in various accident situations, including front, side and rear impacts. The body's frame sections are large in size and as straight as possible, high-strength steel is used where it's effective, and subframe connections help absorb collision energy. Stamping the side frame from a single tailored blank minimizes center pillar deformation during a side impact.

The fuel tank is surrounded by substantial members to guard against leakage in a major rear collision. Six air bags (frontal and side for front occupants, side curtain for all outboard occupants) are standard. A special sensor anticipates a roll-over and inflates the side-curtain air bags early to guard against injury, maintaining inflation for approximately six seconds helps keep limbs out of harm's way.

All seating positions get a headrest and a lap/sash seatbelt. The front seatbelts also use pretensioners and load-limiter mechanisms, while the front seats are designed to minimise whiplash.

The CX-7's brake pedal is designed to breakaway in a major accident, reducing the chance of lower leg injury.

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